What is better Minecraft Spigot or Vanilla?
With Spigot you can add plugins and not with Vanilla.
Usually Spigot is better suited as it has some performance improvements. However, these can sometimes mean that a procedure is slightly different than in the original.
At least if you also want to use plugins, you can no longer use a vanilla server.
Depends on what you want to do.
If you want to build technical stuff like Redstone or Iron Farms, then Vanilla is better, because
Spigot has some performance improvements, but preventing e.g. That iron farms or some Redstone machines work.
From demher:
Minecraft Technology Noob: Spigot
Minecraft technology freak: Vanilla, or more specialized plugin loader.